ZNF728

Across TCGA cell cohorts, ZNF728 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF728-associated genes across cancer lineages are MBD3L1, PRAMEF8, and OR2T11. Each is linked with ZNF728 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF728-to-partner and partner-to-ZNF728 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L1 grouped by ZNF728-low versus ZNF728-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF728→partner) and Y-score (partner→ZNF728) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MBD3L1 →	+0.036	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF8 →	+0.038	+3.523	<.001	.008	3	1
LUNG_SCLC	OR2T11 →	+0.020	+3.817	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR4K1 →	+0.022	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	HSFY1 →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	SCN10A →	+0.006	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MBD3L1 by ZNF728 expression — LUNG_SCLC

Explore this box plot interactively →