ZNF709

Across TCGA cell cohorts, ZNF709 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible ZNF709-associated genes across cancer lineages are OR1E3, OR4S2, and TMEM52B. Each is linked with ZNF709 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF709-to-partner and partner-to-ZNF709 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1E3 grouped by ZNF709-low versus ZNF709-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF709→partner) and Y-score (partner→ZNF709) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR1E3 →	+0.187	+4.285	<.001	.007	3	1
STOMACH	OR4S2 →	+0.015	+4.285	<.001	.007	3	1
SKIN	TMEM52B →	+0.955	+3.453	.001	.009	3	1
SKIN	MMP26 →	+0.013	+4.022	<.001	.006	3	1
SKIN	HES5 →	+0.040	+3.155	.006	.008	3	1
OVARY	ANHX →	+0.240	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR1E3 by ZNF709 expression — STOMACH

Explore this box plot interactively →