ZNF709

Across TCGA pan-cancer cohorts, ZNF709 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ZNF709’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF709 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF709 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, LIHC, and KICH are the cancer types where ZNF709 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF709 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.166	<.001	11	view →
LIHC	All	II,III,IV	+0.075	<.001	7	view →
KICH	Male	All	−0.266	<.001	5	view →
THCA	Male	II,III,IV	−0.268	.001	4	view →
ESCA	All	II,III,IV	+0.390	.045	2	view →
CHOL	All	All	+0.318	<.001	2	view →
COAD	All	All	+0.041	.035	2	view →
BLCA	Female	III,IV	+0.098	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ZNF709–KIRC

Open the KIRC breakdown →