Across TCGA patient cohorts, ZNF681 mutation is significantly associated with the RNA expression of many other genes, with 4,136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF681-associated genes across cancer lineages are WSPAR, RNA5SP131, and CKLF-CMTM1. Each is linked with ZNF681 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF681-to-partner and partner-to-ZNF681 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF681→partner) and Y-score (partner→ZNF681) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	WSPAR →	+0.154	+4.758	<.001	<.001	3	5
BLCA	RNA5SP131 →	+0.172	+5.307	<.001	.001	3	3
SKCM	CKLF-CMTM1 →	+0.352	+2.510	.001	.009	3	3
BRCA	RPL23P4 →	+0.511	+4.506	<.001	.009	3	3
UCEC	TCP1 →	+0.423	+3.052	.001	<.001	3	3
UCEC	PGM3 →	+0.476	+2.080	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,136 associations by consensus.

Exploration

ZNF681 survival (RNA) · tumor vs normal (RNA) · all ZNF681 data types