Q-omics provides the consensus-scored WSPAR profile across patient tissues and cancer cell-line models. WSPAR expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in CESC. Among the 18 cancer types available for tumor–normal comparison, WSPAR is differentially expressed in 7, with the highest sampling consensus in KIRC. Additionally, WSPAR RNA expression shows 6,489 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight CESC, KIRC, and STAD as cancer lineages where WSPAR shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for WSPAR — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes WSPAR survival associations across molecular data types. WSPAR RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible WSPAR RNA expression–survival associations across cancer types. High WSPAR expression shows unfavorable associations in CESC, LIHC, LUSC and COAD, but favorable associations in LGG and STAD. The CESC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify CESC as the clearest survival context for WSPAR RNA expression.
This table summarizes WSPAR tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for WSPAR. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. WSPAR shows lower tumor expression in KIRC, KIRP, KICH, PRAD and BRCA and higher tumor expression in LIHC. The KIRC box plot shows higher WSPAR RNA expression in normal versus tumor tissue (log2 FC = −0.670, t-test p < 0.001).
This table shows molecular features associated with WSPAR in patient tissues and cancer cell lines. In patient samples, WSPAR shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
