WSPAR

Across TCGA pan-cancer cohorts, WSPAR RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of WSPAR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where WSPAR RNA is repressed in tumor relative to normal tissue. In most cancer types WSPAR is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where WSPAR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WSPAR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.670	<.001	12	view →
KIRP	Male	II,III,IV	−0.754	<.001	11	view →
KICH	Female	II,III,IV	−0.874	<.001	10	view →
PRAD	All	All	−0.014	.036	2	view →
LIHC	All	All	+0.011	.023	2	view →
BRCA	All	II,III,IV	−0.008	.018	2	view →
STAD	Female	III,IV	−0.260	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

WSPAR–KIRC

Open the KIRC breakdown →