ZNF680

Across TCGA patient cohorts, ZNF680 mutation is significantly associated with the RNA expression of many other genes, with 3,422 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF680-associated genes across cancer lineages are NFYBP1, RPL35AP3, and LINC02558. Each is linked with ZNF680 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF680-to-partner and partner-to-ZNF680 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NFYBP1 grouped by ZNF680-low versus ZNF680-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF680→partner) and Y-score (partner→ZNF680) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NFYBP1 →	+0.077	+3.975	.004	.006	3	3
READ	RPL35AP3 →	+0.502	+4.533	<.001	.004	3	2
READ	LINC02558 →	+0.185	+4.724	<.001	.003	3	2
READ	DUTP7 →	+0.247	+4.724	<.001	.003	3	2
KIRC	TRDD1 →	+1.498	+8.025	<.001	.007	3	2
CESC	HMGB1P23 →	+0.144	+4.234	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,422 associations by consensus.

NFYBP1 by ZNF680 expression — CESC

Explore this box plot interactively →