ZNF621

Across TCGA patient cohorts, ZNF621 mutation is significantly associated with the RNA expression of many other genes, with 2,909 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF621-associated genes across cancer lineages are RNU1-6P, RNU1-57P, and IGHD2-15. Each is linked with ZNF621 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF621-to-partner and partner-to-ZNF621 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-6P grouped by ZNF621-low versus ZNF621-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF621→partner) and Y-score (partner→ZNF621) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU1-6P →	+0.303	+4.578	<.001	.008	3	2
UCEC	RNU1-57P →	+0.143	+3.662	<.001	.001	3	2
UCEC	IGHD2-15 →	+1.562	+1.776	<.001	.002	3	2
UCEC	SELENOKP3 →	+0.105	+1.879	.006	.002	3	2
UCEC	IGHV1-69D →	+1.909	+2.818	<.001	<.001	3	1
UCEC	LINC01943 →	+0.425	+1.958	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,909 associations by consensus.

RNU1-6P by ZNF621 expression — HNSC

Explore this box plot interactively →