ZNF614

Across TCGA patient cohorts, ZNF614 mutation is significantly associated with the RNA expression of many other genes, with 2,509 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF614-associated genes across cancer lineages are RNU6-502P, POLR2A, and C12orf60. Each is linked with ZNF614 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF614-to-partner and partner-to-ZNF614 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-502P grouped by ZNF614-low versus ZNF614-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF614→partner) and Y-score (partner→ZNF614) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-502P →	+0.642	+5.347	<.001	.006	3	3
UCEC	POLR2A →	+0.529	+2.807	.007	.003	3	2
UCEC	C12orf60 →	+0.312	+2.573	<.001	.008	3	2
UCEC	KMT5A →	+0.438	+2.403	<.001	<.001	3	2
UCEC	RPL23AP82 →	+0.429	+2.403	<.001	<.001	3	2
UCEC	PTP4A3 →	-0.647	-3.796	.003	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,509 associations by consensus.

RNU6-502P by ZNF614 expression — BRCA

Explore this box plot interactively →