ZNF608

Across TCGA patient cohorts, ZNF608 mutation is significantly associated with the RNA expression of many other genes, with 4,905 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF608-associated genes across cancer lineages are GAGE2E, RNA5SP419, and ITPK1. Each is linked with ZNF608 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF608-to-partner and partner-to-ZNF608 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE2E grouped by ZNF608-low versus ZNF608-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF608→partner) and Y-score (partner→ZNF608) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GAGE2E →	+0.445	+5.584	<.001	.003	3	3
LUSC	RNA5SP419 →	+0.396	+4.102	<.001	.007	3	3
UCEC	ITPK1 →	+0.293	+1.748	.003	.002	3	3
SKCM	DHRS7 →	+0.576	+2.851	.001	.001	3	3
UCEC	SMIM8 →	+0.206	+1.502	.004	<.001	3	3
UCEC	GMDS →	+0.529	+1.481	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,905 associations by consensus.

GAGE2E by ZNF608 expression — GBM

Explore this box plot interactively →