ZNF608

Across TCGA pan-cancer cohorts, ZNF608 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZNF608 data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ZNF608 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF608 expression acts as an unfavorable survival marker, although some lineages such as UCS and GBM show a favorable association.

CESC, OV, and KIRP are the cancer types where ZNF608 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Quartile	III,IV	0.567	0.949	.002	60	view →
OV	DFS	Median	All	0.495	0.581	.006	46	view →
KIRP	DFS	Quartile	All	0.494	0.786	<.001	27	view →
ACC	DFS	Tertile	All	0.318	0.674	.002	26	view →
UCS	DFS	Tertile	IV	0.956	0.250	.024	24	view →
STAD	OS	Quartile	All	0.364	0.723	.005	21	view →
UCEC	DFS	Median	All	0.522	0.749	.006	20	view →
GBM	DFS	Median	All	0.387	0.188	.003	18	view →
LAML	DFS	Tertile	All	0.471	0.244	.004	18	view →
BLCA	DFS	Tertile	All	0.214	0.537	.015	16	view →
BRCA	DFS	Tertile	IV	0.376	0.814	.007	11	view →
LUAD	OS	Tertile	All	0.884	0.754	.011	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZNF608–CESC (OS)

Open the CESC breakdown →