ZNF608

Across TCGA pan-cancer cohorts, ZNF608 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF608’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ZNF608 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF608 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, KIRC, and LUSC are the cancer types where ZNF608 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF608 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−2.314	<.001	11	view →
KIRC	Male	All	+0.943	<.001	11	view →
LUSC	Male	II,III,IV	−1.513	<.001	8	view →
KIRP	Male	III,IV	+1.089	<.001	8	view →
HNSC	Male	All	−0.826	<.001	7	view →
BRCA	Female	All	−0.865	<.001	6	view →
LIHC	All	All	+0.468	<.001	5	view →
LUAD	All	All	−0.453	.001	5	view →
COAD	Female	II,III,IV	−0.485	.012	4	view →
CHOL	All	All	+2.118	<.001	3	view →
BLCA	All	III,IV	+0.599	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF608–KICH

Open the KICH breakdown →