ZNF608

Across TCGA patient cohorts, ZNF608 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF608-associated genes across cancer lineages are Notch1, p38-MAPK_pT180_Y182, and PCNA. Each is linked with ZNF608 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF608-to-partner and partner-to-ZNF608 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZNF608-low versus ZNF608-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF608→partner) and Y-score (partner→ZNF608) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.160	+2.676	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.297	-1.227	.025	.015	3	2
UCEC	PCNA →	+0.199	+2.169	.001	.002	3	2
UCEC	Shc_pY317 →	-0.106	-1.584	.018	.032	3	2
UCEC	STAT3_pY705 →	-0.305	-1.706	<.001	.003	3	2
UCEC	Tuberin_pT1462 →	+0.182	+1.502	.007	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Notch1 by ZNF608 expression — UCEC

Explore this box plot interactively →