ZNF608

Across TCGA cell cohorts, ZNF608 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,832 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF608-associated GO terms across cancer lineages are Positive regulation of T cell differentiation, Positive regulation of lymphocyte differentiation, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with ZNF608 in more than 7 cancer types. Because this analysis shows association rather than direction, both ZNF608-to-partner and partner-to-ZNF608 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of T cell differentiation grouped by ZNF608-low versus ZNF608-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF608→partner) and Y-score (partner→ZNF608) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of T cell differentiation →	+0.067	+1.845	.005	.001	3	8
LUNG_NSCLC_LUSC	Positive regulation of lymphocyte differentiation →	+0.090	+2.471	.002	<.001	3	8
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.109	+2.230	<.001	<.001	3	8
OVARY	SMAD protein signal transduction →	+0.124	+2.218	<.001	<.001	3	8
STOMACH	Regulation of nucleotide-excision repair →	+0.139	+1.963	.006	.001	3	8
OVARY	Regulation of myoblast fusion →	+0.110	+2.146	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,832 associations by consensus.

Positive regulation of T cell differentiation by ZNF608 expression — LUNG_NSCLC_LUSC

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