ZNF608

Across TCGA cell cohorts, ZNF608 mutation is significantly associated with the RNA expression of many other genes, with 538 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF608-associated genes across cancer lineages are TMEM207, CBLIF, and PRKACG. Each is linked with ZNF608 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF608-to-partner and partner-to-ZNF608 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM207 grouped by ZNF608-low versus ZNF608-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF608→partner) and Y-score (partner→ZNF608) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TMEM207 →	+0.308	+3.321	.001	.008	3	3
LIVER	CBLIF →	+0.072	+4.000	<.001	.001	3	2
URINARY_TRACT	PRKACG →	+0.005	+4.087	<.001	.009	3	2
BLOOD_Myeloma	ASZ1 →	+0.136	+3.700	.001	<.001	3	2
BLOOD_Myeloma	IQCM →	+0.130	+3.321	.002	.008	3	2
CNS	GYPA →	+0.113	+3.774	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 538 associations by consensus.

TMEM207 by ZNF608 expression — BLOOD_Myeloma

Explore this box plot interactively →