ZNF608

Across TCGA cell cohorts, ZNF608 mutation is significantly associated with the mutation status of many other genes, with 7,041 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF608-associated genes across cancer lineages are ZBED4, PHF20, and ZFR. Each is linked with ZNF608 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF608-to-partner and partner-to-ZNF608 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBED4 grouped by ZNF608-low versus ZNF608-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF608→partner) and Y-score (partner→ZNF608) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZBED4 →	+5.000	+5.000	.006	.006	1	5
LARGE_INTESTINE	PHF20 →	+1.916	+1.667	.009	.009	1	5
LARGE_INTESTINE	ZFR →	+2.501	+1.956	.002	.002	1	5
LUNG_NSCLC_LUAD	CASZ1 →	+3.681	+3.478	.001	.001	1	5
BLOOD_Leukemia	NFASC →	+3.347	+3.235	<.001	<.001	1	5
SOFT_TISSUE	COL22A1 →	+4.137	+5.192	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,041 associations by consensus.

ZBED4 by ZNF608 expression — KIDNEY

Explore this box plot interactively →