ZNF606

Across TCGA patient cohorts, ZNF606 mutation is significantly associated with the RNA expression of many other genes, with 3,274 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF606-associated genes across cancer lineages are TRAIP, GMNN, and RCC1. Each is linked with ZNF606 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF606-to-partner and partner-to-ZNF606 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAIP grouped by ZNF606-low versus ZNF606-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF606→partner) and Y-score (partner→ZNF606) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAIP →	+0.411	+2.415	.002	.003	3	4
UCEC	GMNN →	+0.519	+1.606	<.001	<.001	3	4
UCEC	RCC1 →	+0.435	+1.595	<.001	<.001	3	3
UCEC	RWDD4 →	+0.326	+2.070	.009	.001	3	3
UCEC	ALG12 →	+0.468	+2.119	.004	.002	3	3
UCEC	PGP →	+0.388	+2.000	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,274 associations by consensus.

TRAIP by ZNF606 expression — UCEC

Explore this box plot interactively →