ZNF599

Across TCGA patient cohorts, ZNF599 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF599-associated genes across cancer lineages are MEK1, BRCA2, and C-Raf. Each is linked with ZNF599 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF599-to-partner and partner-to-ZNF599 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZNF599-low versus ZNF599-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF599→partner) and Y-score (partner→ZNF599) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.448	+2.584	<.001	<.001	3	2
UCEC	BRCA2 →	-0.114	-3.541	.007	.002	3	2
UCEC	C-Raf →	+0.171	+2.169	<.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.179	-1.678	.033	.021	3	1
UCEC	eIF4E →	+0.175	+3.598	.013	.001	3	1
UCEC	ERK2 →	+0.175	+3.584	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MEK1 by ZNF599 expression — UCEC

Explore this box plot interactively →