ZNF599

Across TCGA pan-cancer cohorts, ZNF599 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF599’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ZNF599 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF599 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where ZNF599 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF599 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.242	<.001	10	view →
THCA	Male	II,III,IV	−0.747	<.001	9	view →
LIHC	Male	All	+0.414	<.001	9	view →
BLCA	Female	III,IV	+0.572	.014	5	view →
CHOL	All	All	+0.759	<.001	4	view →
UCEC	All	All	−0.626	<.001	4	view →
LUAD	Female	II,III,IV	−0.362	.026	3	view →
READ	All	II,III,IV	−0.250	.030	3	view →
HNSC	All	All	+0.191	.024	3	view →
PRAD	All	All	+0.231	.001	2	view →
LUSC	Male	III,IV	−0.514	.013	1	view →
KIRP	All	All	−0.262	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF599–KICH

Open the KICH breakdown →