ZNF581

Across TCGA patient cohorts, ZNF581 mutation is significantly associated with the RNA expression of many other genes, with 751 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF581-associated genes across cancer lineages are MIR1255B2, SLCO1B3-SLCO1B7, and RPL12P50. Each is linked with ZNF581 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF581-to-partner and partner-to-ZNF581 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1255B2 grouped by ZNF581-low versus ZNF581-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF581→partner) and Y-score (partner→ZNF581) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR1255B2 →	+0.290	+3.335	.004	.004	3	2
UCEC	SLCO1B3-SLCO1B7 →	+0.085	+2.433	.002	.001	3	2
LIHC	RPL12P50 →	+0.392	+5.186	<.001	.007	3	1
UCEC	CTC1 →	+0.469	+2.721	.005	.003	3	1
UCEC	LRRC57 →	+0.526	+3.807	.001	<.001	3	1
UCEC	ZBTB20 →	+0.433	+3.467	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 751 associations by consensus.

MIR1255B2 by ZNF581 expression — UCEC

Explore this box plot interactively →