ZNF581

Across TCGA pan-cancer cohorts, ZNF581 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZNF581’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF581 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF581 is over-expressed in tumor.

KIRC, THCA, and KIRP are the cancer types where ZNF581 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF581 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.082	<.001	12	view →
THCA	Male	III,IV	+1.417	<.001	11	view →
KIRP	Male	II,III,IV	+1.330	<.001	11	view →
COAD	Female	II,III,IV	+1.211	<.001	11	view →
LIHC	Female	II,III,IV	+1.940	<.001	9	view →
BLCA	Male	All	+0.841	<.001	8	view →
LUAD	All	III,IV	+0.652	<.001	8	view →
HNSC	Male	All	+0.559	<.001	8	view →
LUSC	Male	II,III,IV	+0.958	<.001	6	view →
BRCA	All	III,IV	+0.661	<.001	6	view →
CHOL	All	All	+2.736	<.001	5	view →
READ	All	All	+0.653	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZNF581–KIRC

Open the KIRC breakdown →