ZNF581

Across TCGA pan-cancer cohorts, ZNF581 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated ZNF581 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ZNF581 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF581 expression acts as an unfavorable survival marker, although some lineages such as UVM and GBM show a favorable association.

UVM, ACC, and LIHC are the cancer types where ZNF581 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.754	0.412	<.001	118	view →
ACC	DFS	Median	All	0.223	0.677	<.001	114	view →
LIHC	OS	Tertile	All	0.568	0.766	<.001	97	view →
LGG	DFS	Median	All	0.323	0.482	<.001	33	view →
GBM	OS	Quartile	All	0.386	0.202	.002	32	view →
THCA	DFS	Median	IV	0.440	0.865	.001	29	view →
LUSC	DFS	Median	III,IV	0.520	0.783	.001	27	view →
BRCA	OS	Median	All	0.943	0.905	.011	16	view →
SARC	OS	Quartile	All	0.574	0.889	<.001	14	view →
COAD	DFS	Median	II,III,IV	0.589	0.771	.010	13	view →
MESO	DFS	Tertile	III,IV	0.679	0.243	.026	12	view →
LUAD	OS	Median	All	0.287	0.431	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

ZNF581–UVM (DFS)

Open the UVM breakdown →