ZNF581

Across TCGA patient cohorts, ZNF581 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF581-associated genes across cancer lineages are A-Raf_pS299, N-Ras, and p62 Lck ligand. Each is linked with ZNF581 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF581-to-partner and partner-to-ZNF581 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ZNF581-low versus ZNF581-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF581→partner) and Y-score (partner→ZNF581) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.141	-3.000	.019	.036	3	1
UCEC	N-Ras →	-0.123	-2.980	.039	.036	3	1
UCEC	p62 Lck ligand →	+0.608	+3.179	<.001	.010	3	1
UCEC	PDK1_pS241 →	+0.256	+3.169	.002	.019	3	1
UCEC	TSC1 →	+0.255	+2.846	.003	.033	3	1
UCEC	VHL →	-1.089	-2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

A-Raf_pS299 by ZNF581 expression — UCEC

Explore this box plot interactively →