ZNF581

Across TCGA cell cohorts, ZNF581 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF581-associated genes across cancer lineages are FAM181A, FERD3L, and KRT28. Each is linked with ZNF581 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF581-to-partner and partner-to-ZNF581 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM181A grouped by ZNF581-low versus ZNF581-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF581→partner) and Y-score (partner→ZNF581) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM181A →	+0.023	+4.977	<.001	.007	3	1
LARGE_INTESTINE	FERD3L →	+0.079	+4.977	<.001	.007	3	1
LARGE_INTESTINE	KRT28 →	+0.079	+4.977	<.001	.007	3	1
LARGE_INTESTINE	MBD3L2 →	+0.095	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

FAM181A by ZNF581 expression — LARGE_INTESTINE

Explore this box plot interactively →