ZNF577

Across TCGA patient cohorts, ZNF577 mutation is significantly associated with the RNA expression of many other genes, with 3,722 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF577-associated genes across cancer lineages are OR5W2, ZDHHC18, and RN7SKP277. Each is linked with ZNF577 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF577-to-partner and partner-to-ZNF577 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5W2 grouped by ZNF577-low versus ZNF577-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF577→partner) and Y-score (partner→ZNF577) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR5W2 →	+0.070	+5.618	<.001	.002	3	3
UCEC	ZDHHC18 →	+0.353	+1.846	.002	.007	3	3
LUAD	RN7SKP277 →	+0.095	+4.155	<.001	.007	3	3
UCEC	SRSF4 →	+0.444	+2.523	<.001	<.001	3	3
STAD	RNU6-1207P →	+0.460	+3.562	<.001	.007	3	3
STAD	OR2AT2P →	+0.119	+3.252	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,722 associations by consensus.

OR5W2 by ZNF577 expression — BLCA

Explore this box plot interactively →