ZNF577

Across TCGA pan-cancer cohorts, ZNF577 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZNF577 data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF577 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF577 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, BLCA, and SCLC are the cancer types where ZNF577 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.408	0.256	<.001	118	view →
BLCA	DFS	Quartile	II,III,IV	0.596	0.429	.002	62	view →
SCLC	DFS	Median	All	0.629	0.343	<.001	62	view →
LGG	DFS	Median	All	0.289	0.463	<.001	41	view →
KIRC	DFS	Median	All	0.741	0.508	<.001	37	view →
READ	OS	Tertile	III,IV	0.859	0.459	.001	36	view →
COAD	DFS	Median	III,IV	0.451	0.751	.002	27	view →
UCS	DFS	Tertile	All	0.363	0.726	.002	26	view →
SKCM	DFS	Tertile	III,IV	0.404	0.756	.006	25	view →
LUSC	DFS	Quartile	III,IV	0.565	0.821	.006	20	view →
KIRP	DFS	Tertile	IV	0.039	0.765	.010	18	view →
GBM	DFS	Tertile	All	0.459	0.205	.002	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZNF577–HNSC (OS)

Open the HNSC breakdown →