ZNF577

Across TCGA pan-cancer cohorts, ZNF577 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF577’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ZNF577 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF577 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and KIRP are the cancer types where ZNF577 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF577 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.652	<.001	11	view →
KIRC	All	II,III,IV	−0.421	<.001	10	view →
KIRP	All	All	−0.814	<.001	7	view →
BRCA	Female	II,III,IV	−0.389	<.001	6	view →
THCA	All	All	−0.286	.004	6	view →
LUSC	All	All	−0.288	.003	5	view →
CHOL	All	All	+1.157	.002	4	view →
PRAD	All	All	+0.632	<.001	2	view →
UCEC	All	All	−0.446	.014	2	view →
HNSC	All	II,III,IV	−0.223	.023	2	view →
BLCA	Male	IV	−0.592	.032	1	view →
LUAD	Female	II,III,IV	−0.374	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF577–KICH

Open the KICH breakdown →