ZNF577

Across TCGA patient cohorts, ZNF577 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF577-associated genes across cancer lineages are eEF2, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with ZNF577 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF577-to-partner and partner-to-ZNF577 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ZNF577-low versus ZNF577-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF577→partner) and Y-score (partner→ZNF577) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.332	+1.502	.011	.030	3	2
UCEC	EGFR_pY1068 →	-0.347	-2.736	<.001	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.191	-2.584	.002	.010	3	2
UCEC	Notch1 →	+0.148	+1.598	.004	.040	3	2
UCEC	PCNA →	+0.237	+3.321	.002	.009	3	2
UCEC	PDCD4 →	-0.631	-2.247	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

eEF2 by ZNF577 expression — UCEC

Explore this box plot interactively →