ZNF577

Across TCGA cell cohorts, ZNF577 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,880 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF577-associated GO terms across cancer lineages are Regulation of RNA splicing, Negative regulation of myoblast fusion, and Spliceosomal complex assembly. Each is linked with ZNF577 in more than 10 cancer types. Because this analysis shows association rather than direction, both ZNF577-to-partner and partner-to-ZNF577 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by ZNF577-low versus ZNF577-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF577→partner) and Y-score (partner→ZNF577) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of RNA splicing →	+0.076	+1.364	<.001	<.001	3	11
STOMACH	Negative regulation of myoblast fusion →	+0.135	+1.886	.001	.001	3	11
SOFT_TISSUE	Spliceosomal complex assembly →	+0.070	+1.366	.001	<.001	3	11
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.075	+1.416	<.001	.001	3	10
BLOOD_Lymphoma	Regulation of mRNA splicing, via spliceosome →	+0.082	+1.056	<.001	<.001	3	10
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.120	+1.233	.009	.008	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,880 associations by consensus.

Regulation of RNA splicing by ZNF577 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →