ZNF577

Across TCGA cell cohorts, ZNF577 mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF577-associated genes across cancer lineages are BDILV000379a, PRT062607, and Oxaliplatin. Each is linked with ZNF577 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF577-to-partner and partner-to-ZNF577 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BDILV000379a grouped by ZNF577-low versus ZNF577-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF577→partner) and Y-score (partner→ZNF577) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BDILV000379a →	+0.316	+2.649	.041	.046	3	1
LARGE_INTESTINE	PRT062607 →	+0.534	+2.769	.034	.040	3	1
LARGE_INTESTINE	Oxaliplatin →	+0.557	+2.649	.035	.046	3	1
LARGE_INTESTINE	123829 →	+0.607	+2.649	.037	.046	3	1
LARGE_INTESTINE	AZD5438 →	+0.503	+2.777	.041	.038	2	1
LARGE_INTESTINE	Leflunomide →	+0.293	+2.769	.022	.040	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

BDILV000379a by ZNF577 expression — LARGE_INTESTINE

Explore this box plot interactively →