ZNF559-ZNF177

Across TCGA patient cohorts, ZNF559-ZNF177 mutation is significantly associated with the RNA expression of many other genes, with 667 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF559-ZNF177-associated genes across cancer lineages are RNU6-1252P, RNU1-15P, and RNU6-254P. Each is linked with ZNF559-ZNF177 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF559-ZNF177-to-partner and partner-to-ZNF559-ZNF177 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1252P grouped by ZNF559-ZNF177-low versus ZNF559-ZNF177-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF559-ZNF177→partner) and Y-score (partner→ZNF559-ZNF177) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1252P →	+0.263	+7.640	<.001	.009	3	3
UCEC	RNU1-15P →	+0.179	+3.928	<.001	.007	3	2
UCEC	RNU6-254P →	+0.276	+2.387	.007	.005	3	2
UCEC	IFNWP4 →	+0.073	+3.928	<.001	.007	3	2
UCEC	SNX8 →	+0.520	+2.818	.004	.001	3	2
UCEC	RRBP1 →	+0.438	+2.749	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 667 associations by consensus.

RNU6-1252P by ZNF559-ZNF177 expression — BLCA

Explore this box plot interactively →