ZNF559-ZNF177

Across TCGA pan-cancer cohorts, ZNF559-ZNF177 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ZNF559-ZNF177 data layer compared with 3 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ZNF559-ZNF177 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF559-ZNF177 expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUAD show a favorable association.

BLCA, LUAD, and UCS are the cancer types where ZNF559-ZNF177 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.594	0.421	<.001	83	view →
LUAD	OS	Median	All	0.757	0.624	<.001	29	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
ACC	OS	Median	III,IV	0.901	0.593	.003	21	view →
SCLC	OS	Median	IV	0.219	0.729	.003	21	view →
LUSC	DFS	Median	III,IV	0.256	0.491	.009	19	view →
GBM	DFS	Tertile	All	0.445	0.204	.010	16	view →
READ	DFS	Tertile	IV	0.339	0.788	.002	15	view →
LGG	OS	Tertile	All	0.685	0.871	.005	14	view →
MESO	DFS	Tertile	IV	0.120	0.546	.008	12	view →
SKCM	DFS	Median	All	0.664	0.556	.012	11	view →
ESCA	DFS	Tertile	II,III,IV	1.000	0.459	.039	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ZNF559-ZNF177–BLCA (DFS)

Open the BLCA breakdown →