ZNF559-ZNF177

Across TCGA pan-cancer cohorts, ZNF559-ZNF177 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF559-ZNF177’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF559-ZNF177 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF559-ZNF177 is over-expressed in tumor, although a few such as KIRC and UCEC show the opposite, repressed pattern.

KIRC, LIHC, and UCEC are the cancer types where ZNF559-ZNF177 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF559-ZNF177 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.168	<.001	10	view →
LIHC	All	All	+0.063	<.001	5	view →
UCEC	All	All	−0.387	<.001	4	view →
HNSC	All	All	+0.047	.026	3	view →
CHOL	All	All	+0.282	.005	2	view →
THCA	Male	IV	−0.253	.022	2	view →
PRAD	All	All	+0.250	<.001	2	view →
BRCA	All	III,IV	−0.158	.041	2	view →
LUSC	All	II,III,IV	+0.139	.024	2	view →
KIRP	Male	All	−0.134	.018	2	view →
KICH	Male	III,IV	−0.339	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF559-ZNF177–KIRC

Open the KIRC breakdown →