ZNF559-ZNF177

Across TCGA patient cohorts, ZNF559-ZNF177 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF559-ZNF177-associated genes across cancer lineages are EGFR_pY1068, ER-alpha, and GAPDH. Each is linked with ZNF559-ZNF177 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF559-ZNF177-to-partner and partner-to-ZNF559-ZNF177 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF559-ZNF177-low versus ZNF559-ZNF177-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF559-ZNF177→partner) and Y-score (partner→ZNF559-ZNF177) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.238	-2.000	.035	.032	3	2
UCEC	ER-alpha →	-0.929	-2.700	.012	.006	3	1
UCEC	GAPDH →	+0.543	+2.000	.024	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.150	-3.000	.048	.036	3	1
UCEC	MEK1 →	+0.524	+3.459	.001	.005	3	1
UCEC	MSH2 →	-0.231	-3.143	.026	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by ZNF559-ZNF177 expression — UCEC

Explore this box plot interactively →