ZNF556

Across TCGA patient cohorts, ZNF556 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF556-associated genes across cancer lineages are GAPDH, Caspase-7-cleavedD198, and eIF4E. Each is linked with ZNF556 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF556-to-partner and partner-to-ZNF556 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ZNF556-low versus ZNF556-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF556→partner) and Y-score (partner→ZNF556) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.391	+2.321	.047	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.616	+1.827	.004	.015	3	2
UCEC	eIF4E →	+0.202	+3.807	.009	<.001	3	1
UCEC	eIF4G →	+0.302	+1.847	.008	.008	3	1
UCEC	FoxM1 →	+0.246	+1.847	.009	.008	3	1
UCEC	FOXO3a_pS318_S321 →	-0.110	-2.077	.016	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

GAPDH by ZNF556 expression — UCEC

Explore this box plot interactively →