ZNF556

Across TCGA pan-cancer cohorts, ZNF556 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ZNF556’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ZNF556 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF556 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

LUSC, BLCA, and COAD are the cancer types where ZNF556 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF556 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	+0.991	<.001	6	view →
BLCA	All	All	+0.763	.009	5	view →
COAD	All	All	+0.351	.001	5	view →
KIRC	Male	All	−0.341	<.001	5	view →
CHOL	All	All	+0.033	<.001	5	view →
STAD	Female	All	+0.730	.021	4	view →
HNSC	All	II,III,IV	+0.332	.039	2	view →
LIHC	All	All	+0.115	.017	1	view →
COAD	Female	IV	−0.060	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 8 lineages.

ZNF556–LUSC

Open the LUSC breakdown →