ZNF556

Across TCGA pan-cancer cohorts, ZNF556 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZNF556 data layer compared with 10 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ZNF556 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF556 expression acts as an unfavorable survival marker, although some lineages such as KIRP and SKCM show a favorable association.

KIRP, SKCM, and COAD are the cancer types where ZNF556 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	1.000	0.211	<.001	72	view →
SKCM	DFS	Median	All	0.802	0.682	<.001	70	view →
COAD	OS	Tertile	II,III,IV	0.663	0.830	<.001	47	view →
SCLC	OS	Median	II,III,IV	1.000	0.421	.002	40	view →
MESO	OS	Quartile	All	0.676	0.412	.011	36	view →
THYM	DFS	Median	All	0.898	0.611	<.001	24	view →
UCS	OS	Median	All	0.234	0.607	.004	18	view →
CESC	DFS	Median	IV	0.090	0.402	.019	12	view →
KICH	OS	Median	All	0.775	0.967	.018	11	view →
SARC	OS	Quartile	All	0.649	0.919	.001	9	view →
LUAD	DFS	Quartile	II,III,IV	0.567	0.192	.018	9	view →
HNSC	DFS	Median	All	0.565	0.740	.008	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZNF556–KIRP (DFS)

Open the KIRP breakdown →