ZNF550

Across TCGA patient cohorts, ZNF550 mutation is significantly associated with the RNA expression of many other genes, with 4,289 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF550-associated genes across cancer lineages are GPC5-IT1, HMGB1P29, and MRPL32P1. Each is linked with ZNF550 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF550-to-partner and partner-to-ZNF550 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPC5-IT1 grouped by ZNF550-low versus ZNF550-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF550→partner) and Y-score (partner→ZNF550) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	GPC5-IT1 →	+0.263	+4.626	<.001	.004	3	2
READ	HMGB1P29 →	+0.140	+4.533	.001	.004	3	2
CESC	MRPL32P1 →	+0.127	+5.569	<.001	.002	3	2
BLCA	ACTL7A →	+0.049	+4.396	<.001	.006	3	2
BLCA	RNU6-1067P →	+0.304	+4.685	<.001	.007	3	2
UCEC	RNA5SP86 →	+0.441	+2.299	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,289 associations by consensus.

GPC5-IT1 by ZNF550 expression — READ

Explore this box plot interactively →