ZNF550

Across TCGA pan-cancer cohorts, ZNF550 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ZNF550’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF550 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF550 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, LIHC, and BLCA are the cancer types where ZNF550 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF550 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.727	<.001	9	view →
LIHC	Female	All	+0.810	<.001	8	view →
BLCA	All	III,IV	+0.842	<.001	7	view →
LUAD	Male	All	+0.626	<.001	6	view →
CHOL	All	II,III,IV	+2.204	<.001	5	view →
KIRC	All	All	+0.359	<.001	5	view →
HNSC	All	All	+0.305	.012	5	view →
LUSC	Male	All	+0.700	<.001	4	view →
UCEC	All	All	−0.555	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ZNF550–THCA

Open the THCA breakdown →