ZNF519

Across TCGA cell cohorts, ZNF519 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF519-associated genes across cancer lineages are LIM2, MS4A4A, and MSGN1. Each is linked with ZNF519 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF519-to-partner and partner-to-ZNF519 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIM2 grouped by ZNF519-low versus ZNF519-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF519→partner) and Y-score (partner→ZNF519) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LIM2 →	+0.051	+4.963	<.001	.001	3	1
LARGE_INTESTINE	MS4A4A →	+0.219	+3.678	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.329	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.213	+4.155	<.001	.003	3	1
LARGE_INTESTINE	RNF212B →	+0.146	+3.678	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

LIM2 by ZNF519 expression — BREAST

Explore this box plot interactively →