ZNF519

Across TCGA pan-cancer cohorts, ZNF519 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZNF519’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF519 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF519 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where ZNF519 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF519 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.407	<.001	9	view →
KIRC	Male	All	+0.191	<.001	8	view →
KICH	Female	II,III,IV	−0.512	<.001	6	view →
BRCA	Female	All	−0.215	.001	6	view →
CHOL	All	All	+0.900	<.001	5	view →
LIHC	Female	All	+0.171	<.001	5	view →
LUSC	All	All	+0.324	<.001	4	view →
BLCA	Male	IV	−0.702	.015	2	view →
UCEC	All	All	−0.441	.017	2	view →
ESCA	All	All	+0.394	.006	2	view →
LUAD	Female	III,IV	−0.308	.002	2	view →
READ	All	III,IV	−0.215	.044	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZNF519–THCA

Open the THCA breakdown →