Across TCGA patient cohorts, ZNF517 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF517-associated genes across cancer lineages are FoxM1, N-Cadherin, and Shc_pY317. Each is linked with ZNF517 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF517-to-partner and partner-to-ZNF517 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF517→partner) and Y-score (partner→ZNF517) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.271	+2.321	.037	.035	3	2
UCEC	N-Cadherin →	+0.255	+2.321	.016	.035	3	2
UCEC	Shc_pY317 →	-0.230	-2.321	.002	.034	3	2
UCEC	EGFR_pY1068 →	-0.288	-2.321	.022	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.134	-2.321	.033	.035	3	1
UCEC	MEK1 →	+0.451	+3.459	.014	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

ZNF517 survival (RNA) · tumor vs normal (RNA) · all ZNF517 data types