Across TCGA cell cohorts, ZNF517 mutation is significantly associated with the RNA expression of many other genes, with 573 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF517-associated genes across cancer lineages are SPATA48, HIPK4, and FBXW10. Each is linked with ZNF517 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF517-to-partner and partner-to-ZNF517 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF517→partner) and Y-score (partner→ZNF517) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SPATA48 →	+0.008	+4.222	<.001	.006	3	2
LARGE_INTESTINE	HIPK4 →	+0.068	+2.472	.003	.008	3	2
LARGE_INTESTINE	FBXW10 →	+0.220	+2.906	<.001	.001	3	2
BLOOD_Leukemia	CALHM4 →	+0.020	+3.269	<.001	.007	3	1
BLOOD_Leukemia	C1orf185 →	+0.077	+3.772	<.001	<.001	3	1
BLOOD_Leukemia	SCT →	+0.295	+2.906	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 573 associations by consensus.

Exploration

ZNF517 survival (RNA) · tumor vs normal (RNA) · all ZNF517 data types