ZNF516-DT

Across TCGA patient cohorts, ZNF516-DT mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF516-DT-associated genes across cancer lineages are IGHD5-5, MIR1298, and TSPY25P. Each is linked with ZNF516-DT in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF516-DT-to-partner and partner-to-ZNF516-DT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD5-5 grouped by ZNF516-DT-low versus ZNF516-DT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF516-DT→partner) and Y-score (partner→ZNF516-DT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD5-5 →	+1.131	+8.066	<.001	.007	3	1
UCEC	MIR1298 →	+0.373	+8.066	<.001	.007	3	1
UCEC	TSPY25P →	+0.094	+8.066	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

IGHD5-5 by ZNF516-DT expression — UCEC

Explore this box plot interactively →