ZNF516-DT

Across TCGA pan-cancer cohorts, ZNF516-DT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZNF516-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ZNF516-DT RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF516-DT is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

KICH, BRCA, and LIHC are the cancer types where ZNF516-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF516-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.285	<.001	10	view →
BRCA	All	III,IV	+0.444	<.001	6	view →
LIHC	Male	All	+0.292	<.001	6	view →
THCA	Female	II,III,IV	+0.335	.015	4	view →
LUAD	Female	All	+0.289	<.001	4	view →
LUSC	All	All	+0.284	<.001	3	view →
PRAD	All	All	−0.350	<.001	2	view →
COAD	All	II,III,IV	+0.161	.004	2	view →
KIRP	Male	All	+0.122	.022	2	view →
READ	Female	All	−0.186	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZNF516-DT–KICH

Open the KICH breakdown →