ZNF516-DT

Across TCGA pan-cancer cohorts, ZNF516-DT RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ZNF516-DT data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ZNF516-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF516-DT expression acts as an unfavorable survival marker, although some lineages such as BRCA and OV show a favorable association.

UVM, BRCA, and LGG are the cancer types where ZNF516-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.694	0.977	<.001	107	view →
BRCA	DFS	Tertile	III,IV	0.950	0.795	<.001	72	view →
LGG	OS	Median	All	0.852	0.935	<.001	45	view →
OV	OS	Median	All	0.755	0.624	.001	44	view →
UCEC	DFS	Median	All	0.884	0.791	<.001	42	view →
BLCA	DFS	Median	II,III,IV	0.251	0.425	.009	25	view →
KIRP	OS	Median	All	0.927	0.839	.006	24	view →
DLBC	DFS	Tertile	II,III,IV	0.971	0.415	.001	22	view →
ESCA	DFS	Median	II,III,IV	1.000	0.399	.013	21	view →
READ	OS	Tertile	II,III,IV	1.000	0.530	.010	13	view →
PAAD	OS	Median	All	0.471	0.240	.004	12	view →
GBM	OS	Median	All	0.335	0.482	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ZNF516-DT–UVM (OS)

Open the UVM breakdown →