ZNF48

Across TCGA cell cohorts, ZNF48 mutation is significantly associated with the RNA expression of many other genes, with 1,376 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF48-associated genes across cancer lineages are UBXN4, FBXO25, and SGCB. Each is linked with ZNF48 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF48-to-partner and partner-to-ZNF48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBXN4 grouped by ZNF48-low versus ZNF48-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF48→partner) and Y-score (partner→ZNF48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UBXN4 →	+0.648	+3.411	.001	.003	3	2
BLOOD_Leukemia	FBXO25 →	+1.094	+3.351	.001	.003	3	2
BLOOD_Leukemia	SGCB →	+1.701	+3.351	<.001	.003	3	2
BLOOD_Leukemia	GKAP1 →	+1.260	+3.351	<.001	.003	3	2
BLOOD_Leukemia	THAP5 →	+0.877	+3.214	<.001	.006	3	2
BLOOD_Leukemia	MAPT →	+0.982	+3.351	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,376 associations by consensus.

UBXN4 by ZNF48 expression — BLOOD_Leukemia

Explore this box plot interactively →