ZNF48

Across TCGA pan-cancer cohorts, ZNF48 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZNF48 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ZNF48 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF48 expression acts as an unfavorable survival marker, although some lineages such as UVM and HNSC show a favorable association.

UVM, HNSC, and MESO are the cancer types where ZNF48 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.783	0.416	<.001	111	view →
HNSC	DFS	Tertile	IV	0.731	0.551	.003	65	view →
MESO	DFS	Median	IV	0.181	0.528	.001	59	view →
LIHC	DFS	Median	All	0.467	0.615	<.001	38	view →
KIRC	DFS	Tertile	All	0.824	0.521	<.001	37	view →
UCEC	DFS	Median	IV	0.871	0.552	.003	28	view →
SKCM	OS	Tertile	III,IV	0.519	0.283	.007	26	view →
PAAD	OS	Quartile	All	0.559	0.248	.005	21	view →
THYM	OS	Median	All	1.000	0.713	<.001	21	view →
LGG	DFS	Median	All	0.869	0.791	.002	19	view →
READ	OS	Median	All	0.937	0.326	.008	19	view →
BLCA	OS	Median	IV	0.248	0.580	.012	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZNF48–UVM (OS)

Open the UVM breakdown →