ZNF443

Across TCGA cell cohorts, ZNF443 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF443-associated genes across cancer lineages are OLFM3, GPR42, and KERA. Each is linked with ZNF443 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF443-to-partner and partner-to-ZNF443 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OLFM3 grouped by ZNF443-low versus ZNF443-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF443→partner) and Y-score (partner→ZNF443) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OLFM3 →	+0.180	+2.672	.009	.004	3	1
SKIN	GPR42 →	+0.069	+2.672	<.001	.004	3	1
SKIN	KERA →	+0.017	+2.560	.001	.008	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	C14orf180 →	+0.176	+3.155	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OLFM3 by ZNF443 expression — SKIN

Explore this box plot interactively →