ZNF443

Across TCGA pan-cancer cohorts, ZNF443 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF443’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ZNF443 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF443 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

LIHC, STAD, and COAD are the cancer types where ZNF443 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF443 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+0.464	<.001	8	view →
STAD	All	II,III,IV	+0.791	<.001	7	view →
COAD	Male	All	+0.760	<.001	6	view →
BLCA	All	All	+0.631	.009	6	view →
KICH	Female	III,IV	−0.613	.002	6	view →
BRCA	All	II,III,IV	+0.586	<.001	6	view →
UCEC	All	All	+0.560	<.001	6	view →
THCA	Male	II,III,IV	−0.549	.002	4	view →
KIRC	All	III,IV	−0.298	.003	4	view →
CHOL	Male	All	+1.435	<.001	3	view →
READ	All	All	+0.759	.002	3	view →
LUAD	All	All	+0.258	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF443–LIHC

Open the LIHC breakdown →